In our results, minor allele of the rs2272023 (C), rs35430524 (A), rs2882676 (A), rs2351491 (T), rs938609 (A), rs3825994 (G), rs1042630 (A), rs698621 (G) and rs3817428 (G) variants of ACAN were associated with the severity of lumbar disc herniation. The gene discussed is ACAN; the disease is lumbar disc herniation.