Similar to mouse models of rickettsial and viral infections, in which CXCR3+CD8+ T cells and other immune cells contribute to pathogen clearance and pathogenesis [42,43,44,45], CXCR3 and its ligands may play complex roles in OtK-induced neuroinflammation, depending on the infection doses and disease stages. The gene discussed is CD8A; the disease is viral infectious disease.