Finally, during the peer review process of this paper, three new genome-wide significant loci (i.e. PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1) were reported in a trans-ethnic GWAS meta-analysis for AD [68], all of which were among our reprioritized list of risk loci. This evidence concerns the gene ECHDC3 and Alzheimer disease.