Patients with first-episode psychosis who presented with autoantibodies reactive to the N-terminal fragment of PAGE2B (representative for the PAGE2B, PAGE2 and/or PAGE5 proteins) at study inclusion had an increased risk of being diagnosed with a DSM-IV disorder characterized by chronic or relapsing psychotic symptoms (odds ratio (OR) 1.33), in particular schizophrenia (OR 6.7, relative risk 4.6; Figures 4a and b). This evidence concerns the gene PAGE2B and psychotic disorder.