Both germ cell-specific Aire knockout males and females were fully fertile, suggesting that at least in the genetic background investigated (CD1) the depletion of Aire in germ cells was not sufficient to induce a consistent infertile phenotype, as had been reported before in Aire-/- conventional knockout mice (Anderson et al., 2002; Ramsey et al., 2002). This evidence concerns the gene AIRE and Infertility.