Mutations affecting spastin, atlastin-1, reticulon-2, REEP1 and REEP2 account for most cases of autosomal dominant ‘pure’ HSP (Hazan et al., 1999; Zhao et al., 2001; Züchner et al., 2006; Montenegro et al., 2012; Esteves et al., 2014). Here, REEP2 is linked to hereditary spastic paraplegia.