In addition to IgE reactivity against Staphylococcal antigens, IgE reactivity to Escherichia coli (E. coli) antigens and other bacteria of the gut has been detected in about one‐third of patients with AD.15 These findings are unexpected, considering that S. aureus typically induces Th1 or Th17 rather than Th2 immune responses, and nonpathogenic E. coli is associated with immune tolerance rather than with allergic sensitization.16, 17. The gene discussed is IGHE; the disease is Alzheimer disease.