APP and Alzheimer disease: The Tg2576 transgenic murine AD model harbouring the amyloid precursor protein (APP) 695 isoform with the double Swedish mutation [20] exhibits cerebral hypoperfusion from 2 to 3 months of age, which precedes the onset of amyloid plaques that accumulate in the brain of Tg2576 mice from 11 to 13 months of age [21].