Additionally, ligation of the portal vein and coeliac artery in rats was shown to impede the cerebral clearance of Aβ 1–40 peptide [59], suggesting that the aberrant hepatic structural changes we observed in 4- to 5-month-old APP/PS1 mice could negatively impact upon the cerebral clearance of Aβ 1–40 peptide, which could promote amyloid plaque burden and CAA. Here, APP is linked to amyloidosis.