Anti-angiogenic therapies, targeting VEGF, such as sorefenib (blockage of the VEGF tyrosine kinase receptor) and bevacizumab (antibody to VEGF), have been shown to be a promising effective treatment for advanced HCC, and sorafenib has now been approved for the treatment of advanced HCC in both the USA and Europe [4, 5]. This evidence concerns the gene VEGFA and hepatocellular carcinoma.