Using a global assay of fibrinolysis that tested the patient's blood fibrinolytic capacity by application of the euglobulin fraction of plasma to a preformed clot of plasminogen-rich bovine fibrin, Skov et al. [46] demonstrated that fibrinolytic capacity is impaired in VTE patients below 50 years compared with young stroke survivors and this difference remained significant after adjustment for multiple confounders including PAI-1. This evidence concerns the gene PLG and Stroke.