Some earlier studies describing the role of immune cells in GSCs have been generally shown to silence the immune response, escape immune surveillance, for instance, with an ineffective tumor antigen presentation, or release and recruitment of on-site immune suppressive factors (such as TGF-β) and immune suppressive cells (such as immunosuppressive B-cells and myeloid cells) (55). Here, TGFB1 is linked to neoplasm.