DAPK1 and cancer: Down-regulation of DAPK1 expression through promoter methylation has been shown to be a prognostic factor in various types of cancer, including chronic lymphocytic leukemia (Raval et al., 2007), chronic myeloid leukemia (Qian et al., 2009), diffuse large B-cell lymphoma (Kristensen et al., 2014), cervical cancer (Feng et al., 2005), esophageal cancer (Brabender et al., 2009) and lung cancer (Feng et al., 2008).