NFKB1 and leukemia: AM induces apoptosis and cell cycle arrest in human colon cancer DLD-1 cells (Matsumoto et al., 2005), apoptosis in human breast cancer MCF-7 cells with regulation of NF-κB and Hsp70 protein modulation (Ibrahim et al., 2014b), apoptosis in human breast cancer MDA-MB-231 cells by NF-κB and HSP70 signaling pathways (Ibrahim et al., 2014a), and mitochondrial dysfunction in human leukemia HL60 cells (Matsumoto et al., 2004) .