The data indicating that at least twodifferent proteins mediate calcium entry by the store-operated mechanism wasalso obtained in HD models: Neuro-2a mouse neuroblastoma cells and a primaryculture of mouse striatal neurons [16].Using patch-clamp and RNA interference, the authors found that the pore-formingproteins Orai1 and TRPC1 together maintain SOCE in cells that express anN-terminal fragment of mHtt with 138Q, which may be explained by the existenceof a heteromeric channel containing subunits of Orai1 and TRPC1 [16]. Here, ORAI1 is linked to Huntington disease.