REN and atherosclerosis: It should be noted, a study showed that high-fat diet (2% cholesterol) can create atherosclerosis in arteries such as aorta, carotid and renal arteries.14 In this regard, Krämer et al showed that in rats exposed to hypoxia condition (8%) for 6 hours, plasma renin activity RAS increased up to four-fold; furthermore, the levels of renin mRNA increased15 which is consistent with our results.