FADS2 and atherosclerosis: In support of this hypothesis positive correlation between linoleic acid intake and new atherosclerotic lesions formation has been demonstrated.30 Another explanation for higher levels of linoleic acid and lower levels of other unsaturated fatty acids in aortic tissue comparing saphenous vein can be reduced activity of delta-6-desaturase in aorta as has been suggested previously.19 The ω6 fatty acids such as linoleic acid as proinflammatory factor can activate vascular endothelial cells and consequently may cause atherosclerosis.31,32