One possible explanation is that despite possessing highly elevated levels of EGFR protein, ovarian tumors present only rarely with EGFR mutations, while response to EGFR TKIs in other tumor types such as non-small cell lung cancer (NSCLC) is highly dependent on the presence of mutated EGFR [54, 55]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.