In particular, the majority of papillary thyroid carcinomas displayed a 3- to 5-fold decrease of D6/ACKR2 mRNA, while three out of four anaplastic thyroid carcinomas exhibited a 10- to 50-fold decrease of D6/ACKR2 expression (Figure 2). Here, ACKR2 is linked to thyroid gland undifferentiated (anaplastic) carcinoma.