TP53 and cervical squamous intraepithelial neoplasia: ∼84% of sporadic CRC has genetic instability characterized by chromosomal instability (CIN), whereas as ∼13–16% has hypermutation and show microsatellite instability [4] due to defective DNA mismatch repair (MMR), often associated with wild-type tumor protein p53 (TP53) and a near-diploid pattern of CIN.