And its activity occurs through the regulation of different signaling pathways like β-catenin/Tcf or AMP-activated protein kinase (AMPK) in colon cancer cells [20, 21], NF-κB and AP-1/JNK in human hepatoma cells [22], or EGFR/PI3K/Akt pathway in prostate cancer [13] and EGFR in liver cells [12]. Here, HNF4A is linked to colonic neoplasm.