REC8 and gastric cancer: Other EBV-driven aberrant CpG island promoter hypermethylation in human gastric cancer include EPH receptor B6 (EPHB6), MAM domain containing glycosylphosphatidylinositol anchor 2 (MDGA2), interleukin-15 receptor alpha (IL15RA), scavenger receptor class F member 2 (SCARF2), somatostatin receptor 1 (SSTR1), and Rec8 homolog (REC8) (Figure 3) [156].