In the case of HBV-related HCC, accumulation of HBV-induced ROS influences hepatocarcinogenesis by establishing epigenetic silence in the suppressor of cytokine signalling 3 (SOCS3) promoter through upregulation of Snail expression and activation of DNMT1 and HDAC1 in HBV-related HCC. The gene discussed is HDAC1; the disease is hepatocellular carcinoma.