Recently, Shapiro et al. investigated the role of several established pretreatment prognostic factors, such as age, sex, weight loss, and clinical TNM stage in neoadjuvant-treated EC patients [60], but hardly any data is available, evaluating the prognostic role of preoperative levels of CRP and albumin, GPS, mGPS, and C/A ratio in neoadjuvant-treated esophageal cancer. The gene discussed is ALB; the disease is esophageal cancer.