EZH2 and allergic asthma: Our results using human PBMCs showed a lower expression of Ezh2 in the Th2 cells of the patients with AR, suggesting that less gene repression can facilitate Th2 cell differentiation, which is consistent with a previous in vivo mice study where the loss of Ezh2 caused accumulation of memory phenotype Th2 cells that mediated the development of allergic asthma (10).