Interestingly, an increased influx of GR1+Ly6G+ PMN cells was seen in the lungs of WT mice in comparison with Nlrp3−/−, Casp1/11−/−, and Asc−/− mice at 48 h, 2 and 4 weeks of infection (Figure 4D). The gene discussed is NLRP3; the disease is infection.