CASP1 and infection: Regulatory T cells were characterized by the CD4+CD25+FOXP3+ phenotype as shown in the Figure 6A. An increased number of Treg cells was observed in the lungs of Nlrp3−/−, Casp1/11−/−, and Asc−/− at 4 and 10 weeks of infection, compared with WT mice, which also showed increased number of these cells, although lower than NLRP3 components deficient mice (Figure 6B).