NLRP3 and paracoccidioidomycosis: The analysis of intracellular cytokines revealed that NLRP3 played an important role in the induction of Th1 and Th17 responses with concomitant reduction of Th2/Treg expansion, a process of immune regulation associated with regressive disease in both humans and experimental models of PCM (2, 3, 5–8, 10).