CASP1 and paracoccidioidomycosis: To evaluate the function of NLRP3 inflammasome in pulmonary PCM, we first investigated the control of fungal burdens by WT and NLRP3 inflammasome deficient (Nlrp3−/−, Casp1/11−/−, and Asc−/−) mice i.t. infected with (1 × 106) yeasts cells.