These associations included: higher IL-6 and IL-8 were associated with a higher incidence of depression at 6 months (37), TNF-a levels with depression at 12 months (37), IL-5/IL-8/IL-12/TBF with apathy at 12 months (38), TNF-a with disinhibition at 12 months (39), and sVCAM/sICAM/sFAS with depression at 6 months (40). This evidence concerns the gene TNF and major depressive disorder.