Symptoms such as hypercalcemia, renal impairment, anemia, bone lytic lesions, lymphadenopathy, and hepatosplenomegaly are generally accepted as part of the diagnosis criteria for plasma cell disorders, but in reality, these typical presentations may be either absent or nonrevealing in particular cases such as MGUS or POEMS, where a rather weak presence of M-protein can easily be overlooked owing to the large abundances of physiological serum proteins. Here, MYOM2 is linked to hypercalcemia disease.