Glibenclamide inhibited NLRP3 inflammasome activation and subsequently protected against organ inflammation and tissue damage either in a cerulean-induced obese mouse model of SAP, or in an adenine-diet rat model of chronic kidney disease, or in a cyclophosphamide-induced rat model of bladder inflammation, or in a lipopolysaccharide-induced myocardial injury in streptozocin-induced diabetic rats [13, 14, 16, 59]. This evidence concerns the gene NLRP3 and chronic kidney disease.