The specific depletion of IκBζ in lymphocytes or myeloid cells does not induce inflammation in the conjunctiva and ocular skin, although enhanced apoptosis in IκBζ-deficient epithelial cells is involved in the onset of Sjögren’s syndrome-like autoimmune disease in IκBζ−/− mice24. The gene discussed is NFKBIZ; the disease is autoimmune disease.