We next addressed skin-resident T-cell subsets and found that γδhigh T cells with few CD4 and CD8 T cells were present in the skin of Nfkbiz+/− mice, but Nfkbiz−/− mice with AD had massive infiltration of CD4, CD8, and γδmid T cells (Fig. 2B). This evidence concerns the gene CD4 and Alzheimer disease.