The levels of transepidermal water loss (TEWL), which show abnormal skin barrier function, and of serum IgE Ab, which has a positive correlation with the severity of atopic dermatitis and psoriasis27, 28, was higher in the Nfkbiz−/− mice than in Nfkbiz-sufficient (Nfkbiz+/−) mice (Fig. 1C). This evidence concerns the gene IGHE and atopic eczema.