The levels of membrane-associated lysosomal proteins LAMP-1, LAMP-2 and V-ATPase B1/2 (Fig. 1C), and intraluminal proteins including Saposin D and PPT-1 are increased in AD-ANCL patients in the occipital lobe (Supplementary Fig. 1A). The gene discussed is PSAP; the disease is Alzheimer disease.