Of the 40 genes with the highest gene importance scores, 12 genes, PSMG1, PTGER4, CPEB4, EGR2, RFX3, IL1R1, LRRK2, GPR183, ZMIZ1, ELMO1, TNFSF11, SATB2 are associated with other autoimmune diseases than SLE according to the GWAS catalog (Table 1). The gene discussed is EGR2; the disease is autoimmune disease.