Notably, the ZNF804A and the ANK3/CDK1 genes obtained the fifth and sixth highest gene importance scores in the random forest classification, and thus the probability for them being true risk genes for SLE can be considered as high, since all but two other genes reaching rank 20 or higher were known SLE genes identified by GWAS. The gene discussed is CDK1; the disease is systemic lupus erythematosus.