Unique top genes in lupus nephritis defined by the “case-case” prediction are SLC2A13, ZMIZ1, TRIB1, RASGRP3, RMI2, and IPMK. RASGRP3 has so far been associated with SLE only in Asian populations27, where the incidence of lupus nephritis is higher than in Caucasians. Here, RASGRP3 is linked to lupus nephritis.