An analysis of the semi-direct and direct PPIs between Alzheimer’s disease and neoplasms identifies the interaction between the apoptosis regulator BAX, from BCL2 apoptosis regulators family (PF00452) and the BH3-interacting domain death agonist BID (PF06393) (PDB code 4BD247), a pro-apoptotic regulator which promotes BAX oligomerization (see Reed48 and references therein). The gene discussed is BCL2; the disease is early-onset autosomal dominant Alzheimer disease.