For example, the association between rheumatoid arthritis and liver cirrhosis is an indirect link between the metalloproteinase Inhibitor 2 (Uniprot accession P16035), associated with cirrhosis and the ubiquitinous collagenase type 2 (Uniprot accession P08253), associated with rheumatoid arthritis, with three mutations in the interface directly associated with rheumatoid arthritis. This evidence concerns the gene TIMP2 and rheumatoid arthritis.