In addition, we have also reported in our study population that C-peptide concentrations are inversely associated with plasma PL delta-5-desaturase (D5D) EAEs (i.e., the ratio of ARA/DGLA) even after adjusting for obesity (i.e., BMI and WC)27. This evidence concerns the gene FADS1 and obesity due to melanocortin 4 receptor deficiency.