Performing comprehensive mining of cancer genomic alterations in The Cancer Genome Atlas (TCGA) and other cancer genomic databases, we observed RXRAS427F/Y, located in the ligand-binding domain (LBD) of RXRα, as hotspot mutations specifically enriched in bladder cancer (4.3%, 23/534)23–25 (Fig. 1a, Supplementary Fig. 1). This evidence concerns the gene RXRA and urinary bladder carcinoma.