Supporting this finding, overexpression of RXRαS427F/Y but not RXRαWT significantly enhanced ligand-independent expression of known PPARγ target genes ANGPTL4 and PLIN237,38 in several human bladder cancer lines (Fig. 3b, Supplementary Fig. 10a) and in the immortalized normal bladder line SV-HUC-1 (Supplementary Fig. 10b), confirming the general role of RXRαS427F/Y in regulating PPARγ function. The gene discussed is PPARG; the disease is urinary bladder carcinoma.