NLRP3 and colitis: Following our results showing that blockage of autophagy in Il-10−/−mice was NLRP3-dependent, and that hypoxia reduces NLRP3 expression concomitantly with the activation of autophagy in the DSS and Il-10−/−mouse models of colitis, as well as cultured IECs, we sought to determine the role of NLRP3 in the regulation of autophagy.