ORMDL3 and skin disorder: These include 1) Lung function parameters are associated with genetic variants in ORMDL3, with polymorphisms having a significant interaction with place of residence; 2) Frequency of bronchitis is associated with variants in the LT-α gene; 3) Dermatitis risk is related to the genotype distribution of LT-α SNP rs2844484, with a significant interaction with place of residence.