TNF and Hypertension: CaMKII (calcium/calmodulin-dependent protein kinase type 2) is proposed to regulate inflammation (Cfb, Tnfa, and Il-6) and cardiomyogenesis in response to hypertension-related pressure overload, β-adrenergic agonists, or myocardial infarction-induced cell injury.30 Thus, Cfb may contribute to both cardiac inflammation and hypertrophy in response to stress, possibly through regulation of cardiomyogenic gene expression.