CFB and metabolic syndrome: The rat Cfb gene resides within the major histocompatibility region on chromosome 20p12.18 In SHR, this region has been demonstrated to be important in blood pressure regulation,19 serum cholesterol, adiposity, and glucose tolerance.20,21 In this study, we knocked out Cfb in SHR to test the hypothesis that Cfb is necessary for the full expression of cardiometabolic pathophysiological traits in this model of MetS.