Conversely, high molecular-weight adiponectin in humans is lower in obese, insulin-resistant compared with lean, insulin-sensitive individuals.25 However, adiponectin deficiency in mice has been shown to have no effect on glucose homeostasis on a normal diet.26,27 Further, infusion of adiponectin in high-fat fed SHRs only marginally reduced insulin levels without affecting energy expenditure or hypertension.28 Taken together with the observed metabolic improvements, this suggests other mechanisms, besides adiponectin, drive insulin sensitization in the Cfb−/− rat. The gene discussed is ADIPOQ; the disease is hypertensive disorder.