SELP and deep vein thrombosis: Venous thrombus formation induced by flow distortion is based on endothelial activation, release of WPB components, and recruitment of innate immune cells and platelets, which precede thrombosis.13,17 Prevention of recruitment of immune cell, for example, in P-selectin–deficient mice, or platelets, results in strong protection against DVT.13,17 Thus, mechanisms of DVT in this model include not only blood coagulation but also elements of sterile inflammation.