In this context, the correlation found byBridel et al. [38] in an AD biomarker studybetween QC activity and CSF levels of Aβ peptides, adhesion molecules (ICAM1,VCAM1) as well as members of the VEGF pathway (VEGFD and Flt1) is remarkable.Co-regulation of these molecules may be at least partially NF-κB or CX3CL1dependent [24]. This evidence concerns the gene FLT1 and Alzheimer disease.