TLR4 and Anxiety: An important finding of this study is the demonstration that TLR4 response participates in the effects of ethanol during the developing brain, since mice lacking the TLR4 function (TLR4-KO) are protected against ethanol-induced microglia activation, cytokine/chemokine release, myelin and synaptic alterations, and also against the long-term memory and anxiety-like behavior impairments.