Interestingly, blocking microglial activation by administering pioglitazone, an agonist of PPAR (peroxisome proliferator-activated receptor)-γ [14], or resveratrol [15], with anti-inflammatory and antioxidant effects, abrogates the upregulation of brain inflammatory signaling and neuronal death, and prevents some cognitive deficits in neonates. Here, PPARA is linked to Cognitive impairment.