IGF1 and cancer: The available reports on flaxseed lignans focus mostly on animal normal ovaries, not cancer, such as the work on END and ENL inhibiting estrogen metabolism by down-regulating IGF, AKT and NF-kB pathway while up-regulating CYP1A1 expression to protect hen ovary [22] and the work on flaxseed feeding to inhibit inflammation as well as the estrogen related pathway and block inflammation along with the microenvironment changes in the hen ovaries [23].