Mutations in BRCA1 and BRCA2 predispose to hereditary breast and ovarian cancer (HBOC) syndrome characterized by multiple family members affected with breast or ovarian cancer or both, early onset of BC, bilateral form of cancer, and the appearance of other cancers in family members, including prostate, pancreatic and male BC [6]. This evidence concerns the gene BRCA2 and Hereditary breast and ovarian cancer syndrome.