The potential functional T1D SNPs within known T1D candidate genes such as GLIS3, ERBB3, CTRB1, CTSH, FUT2, IL27, SKAP2, TNFAIP3 and PTPN2 had highly significant distal chromosomal interactions including enhancers and lncRNAs that are worthy of specific laboratory investigations (Fig. 2). Here, GLIS3 is linked to type 1 diabetes mellitus.