Taken together, of 23 individuals with SDH-related familial pheochromocytoma and/or paraganglioma, two were heterozygous for SDHAF3 c.157 T > C, giving a MAF of 0.0435 (Table 1) which was not significantly different from our Australian population of healthy controls (p = 0.646) nor from the 1000 Genomes (Phase 3_ALL) (p = 0.106) or ExAC (p = 0.251) populations (Table 1). This evidence concerns the gene SDHB and paraganglioma.