CD40 and atherosclerosis: CD40:TRAF6 has a critical role in promoting atherosclerosis, as attenuated atherosclerosis and reduced Ly6C+ MC and M1 MØ were observed in CD40−/−TRAF6−/−ApoE−/− but not in CD40−/−TRAF2/3/5−/−ApoE−/− mice [47].