In the current study, using an oncogenic Kras-mediated and cerulein-induced mouse model of chronic pancreatitis in LSL-KrasG12D; Pdx1-Cre (KC) mice, as well as LSL-KrasG12D/+; Trp53fl/+; Pdx1-Cre (KPC) mouse model, we aimed to further investigate the cancer preventive and therapeutic effects of metformin. Here, KRAS is linked to chronic pancreatitis.