We found significant differences between NIHL cases and controls for genotypic distributions of SNPs rs1049216 and rs6948 in CASP3. In rs1049216, compared with the participants carrying CC genotypes, the carriers with TT genotype had a decreased risk of NIHL (OR = 0.246, 95% CI = 0.069–0.886). The gene discussed is CASP3; the disease is noise induced hearing loss.