The risk of developing at least three components of MS was associated with FTO polymorphisms (rs3751812: OR = 1.49, CI [1.04–2.14], P = 0.03, power = 61%; rs8050136: OR = 1.52, CI [1.06–2.19], P = 0.02, power = 65%; rs9939609: OR = 1.59, CI [1.10–2.32], P = 0.01, power = 72%) and FABP2 polymorphism (rs1799883: OR = 1.65, CI [1.16–2.38], P = 0.006, power = 82%; Additional file 9). Here, FTO is linked to myeloid sarcoma.