AKT1 and cancer: As shown in Fig. 6a, obviously more DEUs in “immune system”, “infectious diseases”, “cancer” and “signal transduction involved in immune” were detected in clone H than in clone A+ and F. Consistent with the results of all DEUs identified from d-A+ vs c-A+, d-F vs c-F and d-H vs c-H (Fig. 3d), the number of DEUs unique in resistant clone was greater than those in susceptible clone A+ and F, except “complement and coagulation cascades”, “antigen processing and presentation”, “cytosolic DNA-sensing pathway” and “PI3K-Akt signaling pathway” (Fig. 6b).