Starting from some cinnamic acids (particularly ferulic and caffeic) and the diterpenoid rosmaricine, 17 new sulfurated hybrid molecules were synthesised and their ability to in vitro inhibit STAT3 and NF-κB transcription factors as well as their cytotoxicity on the human colon carcinoma cell line (HCT-116) were evaluated. This evidence concerns the gene NFKB1 and colon carcinoma.