To determine the expression levels of Bcl6 during EBV infection of primary B-cells, 10 million human peripheral blood mononuclear cells (PBMCs) from two donors, respectively, were infected with wild-type BAC-GFP-EBV or EBNA3C-deleted (ΔE3C) BAC-GFP-EBV. The gene discussed is BCL6; the disease is Epstein-Barr virus infection.