Bcl6 is indispensable for GC formation and somatic hypermutation (SHM) during B-cell development, thus chromosomal translocations and mutations of Bcl6 regulatory region lead to the deregulation of Bcl6 expression in about 40% DLBCL and 5–10% FL [46]. Here, BCL6 is linked to diffuse large B-cell lymphoma.