The chromosomal translocations of Bcl6 regulatory region referred to as promoter substitution, and frequent mutations of the 5’ noncoding region of Bcl6 result in its deregulated expression, suggesting a key role for Bcl6 in pathogenesis of B-cell lymphoma [12,13,66,67]. Here, BCL6 is linked to B-cell non-Hodgkin lymphoma.